EVENT SCHEDULE

4:30pm – 6:30 pm

Conference Welcome and Keynote Address

6:30 pm – 9:00 pm

Welcome Reception: Meet fellow scientists within the drug discovery industry, while enjoying delicious hors d’oeuvres and cocktails. Enjoy the beautiful views from the Ocean Terrace and the sweet sounds of a steel drum band.

KEYNOTE SPEAKERS

Dr. Terrance Peter Kenakin- Professor of Pharmacology, University of North Carolina
Bio: Beginning his career as a synthetic chemist, Terry Kenakin then obtained Ph.D.in Pharmacology at the University of Alberta, Edmonton Canada. After a post-doctoral Fellowship at University College London, U.K., he joined Burroughs-Wellcome as an associate Scientist. From there he continued working in drug discovery at Glaxo Inc., GlaxoWellcome, and GlaxoSmithkline . Dr Kenakin has been involved in drug discovery for over 30 years. He left industry and joined the Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC in 2011. Currently he is engaged in studies aimed at the optimal design of drug activity assays systems as well as the discovery and testing of allosteric molecules. He is a member of numerous editorial boards as well as Editor in Chief of the Journal of Receptors and Signal Transduction and Co-Editor in Chief of Current Opinion in Pharmacology. In addition, he has authored numerous articles and has written 10 books on Pharmacology.

Presentation Title: “A Perfect Storm comes to Pharmacology: The Emergence of Receptor Allostery and Biased Signaling”

7:00 am – 9:00 am

Breakfast: Come and go as you wish !

9:00 am -10:00 am

Session 1, Part 1: Deciphering and Screening Human Targets: from Oncology and Rare Diseases

Michelle Arkin – UCSF, USA: Tackling tauopathy : new targets, assays, and molecules

10:00 am – 10:30 am

Morning Break and Poster Exhibit: View scientific posters detailing the use of HTRF technology. Attendees can share their results, sparking new and creative scientific ideas.

10:30 am -12:00 pm

Session 1, Part 1: Deciphering and Screening Human Targets : from Oncology and Rare Diseases

Priya Vazirani – PTC Therapeutics, USA: Developing small molecules to treat rare neuromuscular diseases

Akira Ohta – Kyoto University, Japan: iPSC-derived monocytic cell lines use as a platform for phenotype-screening

Martha Kimos – Lieber Institute, USA: Development of an HTRF assay for the detection and characterization of inhibitors of catechol-O-methyltransferase.

12:00 pm -1:30 pm

Lunch

1:30 pm – 3:00 pm

Session 1, Part 2: Deciphering and Screening Human Targets: from Oncology and Rare Diseases.

Jeff Jerman – MRC Tech, UK: Identification and characterization of allosteric modulators of the Dopamine D1 receptor : The utility of HTRF and incorporation into generalized screening strategies

Hidenori Ichijo – Tokyo University, Japan: ER stress-dependent motoneuron toxicity and PPI-targeted drug screening in ALS.

3:00 pm – 3:30 pm

Afternoon Break and Poster Exhibit: View scientific posters detailing the use of HTRF technology. Attendees can share their results, sparking new and creative scientific ideas.

3:30 pm – 5:00 pm

Session 1, Part 2: Deciphering and Screening Human Targets: from Oncology and Rare Diseases

James Bennett – SGC Oxford, UK: Chemical Tools for Exploring Epigenetic Pathways

Xavier Jacq – Mission Therapeutics, UK: Ubi-SphereTM: a unique drug discovery platform for identification and characterization of DUB inhibitors

6:00 pm – 8:00 pm

Lobster Bake: Enjoy a Cape Cod tradition! Attendees will feast on local favorites including New England clam chowder, Maine lobster, steamed Tclams, grilled steaks, BBQ chicken and fresh corn on the cob. Enjoy the energetic, dynamic, upbeat music of Groove Authority, a popular New England band from Boston, MA

8:00pm -10:00pm

Beach Bonfire: Appreciate the natural beauty of a Cape Cod beach. Roasting marshmallows, making s’mores and sipping cocktails are a few of the things you can do at the Beach Bonfire. Attendees will find themselves drifting away to the acoustic stylings of Groove Authority and the sounds of the crashing waves.

7:00 am – 9:00 am

Breakfast: Come and go as you wish !

9:30 am -10:00 am

Session 2: Tailoring HTRF Assays to Discovery in Metabolic Diseases.

Lesley Jenkinson – Medimmune, UK: Cell Based Assays in Biologics Drug Discovery

10:00 am – 10:30 am

Morning Break and Poster Exhibit: View scientific posters detailing the use of HTRF technology. Attendees can share their results, sparking new and creative scientific ideas.

10:30 am -12:00 pm

Session 2: Tailoring HTRF Assays to Discovery in Metabolic Diseases.

Richard Frisbee – Pfizer, USA: Development of high-throughput human whole blood assays using HTRF®

Derek Poore – GSK, USA: Cellular HTRF Based High Throughput Screening: Parameters To Identify Quality Hits

David Harden – BMS, USA: Expanding the use of HTRF through multiplexing in large scale screening.

12:00 pm -1:30 pm

Lunch

1:30 pm – 3:00 pm

Session 3: Streamlining Screening Processes using HTRF

JP Fortin – Pfizer, USA: Novel pharmacological approaches to target the melaocortin-4 receptor

Stephane Dalle – IGF, France: HTRF technology to decipher GPCR-signaling pathways controlling pancreatic beta-cell function and survival: Development and implications for innovative therapeutic strategies

Jacqueline Naylor – MedImmune, UK: HTRF cAMP Assay: Translation from in vitro potency to in vivo efficacy for novel Diabetes therapeutics

3:00 pm – 3:30 pm

Afternoon Break and Poster Exhibit: View scientific posters detailing the use of HTRF technology. Attendees can share their results, sparking new and creative scientific ideas.

3:30 pm – 5:00 pm

Session 3: Streamlining Screening Processes using HTRF

Oliver Mace – Heptares, UK: Modulating enteroendocrine cell signaling to deliver differentiated GLP-1 secretion

Joseph Gunnet – Janssen, USA: Characterization of GPR40 Agonists using HTRF-Based Functional Cell Assays

Andrea Basso – Merck & Co, USA: HTRF from well to clinic: development of a multipurpose phospho-VASP assay

5:00 pm 5:15 pm

Conference Close

7:00 am-5:00 pm

Provincetown Excursion: This optional full day event will include visiting the tip of Cape Cod, exploring what Provincetown, MA has to offer. Attendees will participate in an interactive whale watch and afternoon lunch. After the meal guests will have the opportunity to wander the streets of downtown, visiting landmarks and boutique shops.

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